2 ALS Cases May Be Linked to Gardasil Vaccine

Researchers believe that there may be a link between a vaccine against cervical cancer and a rapidly progressive, fatal disease known as amyotrophic lateral sclerosis (ALS) in two young women.
www.webmd.com/sexual-conditions/hpv-genital-warts/news/20091016/rare-disease-may-be-linked-vaccine?fbclid=IwAR0lFI15zyMn3DzNbS4j2W_ml3XFlFgwROlCq4q0EMGCanp-Cmp56CV7PuY#1


Adolescent Premature Ovarian Insufficiency Following Human Papillomavirus Vaccination.

Idiopathic premature ovarian insufficiency following HPV vaccination.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528880/


Adverse events following HPV vaccination, Alberta 2006–2014. 

Of the women who received HPV vaccine 958 were hospitalized and 19,351 had an emergency department visit within 42 days of immunization.
http://www.sciencedirect.com/science/article/pii/S0264410X16002036?via%3Dihub


A case–control study of quadrivalent human papillomavirus vaccine-associated autoimmune adverse events. 

It was observed that…arthritis, systemic lupus erythematosus, vasculitis, alopecia, or CNS conditions were significantly more likely than controls to have received HPV vaccine.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475239/


Current Safety Concerns with Human Papillomavirus Vaccine: A Cluster Analysis of Reports in VigiBase.

A number of safety signals—complex regional pain syndrome, postural orthostatic tachycardia syndrome, and chronic fatigue syndrome—have emerged with human papillomavirus (HPV) vaccines.
https://link.springer.com/article/10.1007/s40264-016-0456-3


Hypersensitivity reaction to human papillomavirus vaccine due to polysorbate 80.

A 17-year-old girl reported generalised urticaria, eyelid angioedema, rhinitis and conjunctivitis, dyspnoea and wheezing 1 hour after third intramusclar administration of quadrivalent human papillomavirus vaccine.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351639/


Peripheral sympathetic nerve dysfunction in adolescent Japanese girls following immunization with the human papillomavirus vaccine.

The most common previous diagnosis in the studied girls was psychosomatic disease. The social problems of the study participants remained unresolved in that the severely disabled girls stopped going to school.
https://www.ncbi.nlm.nih.gov/m/pubmed/25274229/


Postural tachycardia syndrome following human papillomavirus vaccination.

Six patients developed new onset postural tachycardia syndrome 6 days-2 months following human papillomavirus vaccination.
https://www.ncbi.nlm.nih.gov/m/pubmed/24102827/


Human papillomavirus vaccines, complex regional pain syndrome, postural orthostatic tachycardia syndrome, and autonomic dysfunction – a review of the regulatory evidence from the European Medicines Agency.

Possible association between exposure of young women to human papillomavirus (HPV) vaccines and two “dysautonomic syndromes” (a collection of signs and symptoms thought to be caused by autoimmunity) – complex regional pain syndrome (CRPS) and postural orthostatic tachycardia syndrome (POTS) –
https://www.ncbi.nlm.nih.gov/m/pubmed/27867145/


Suspected Adverse Effects After Human Papillomavirus Vaccination: A Temporal Relationship Between Vaccine Administration and the Appearance of Symptoms in Japan. 

In Japan, after receiving human papillomavirus vaccination, a significant number of adolescent girls experienced various symptoms, the vast majority of which have been ascribed to chronic regional pain syndrome, orthostatic intolerance, and/or cognitive dysfunction. 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688202/


Orthostatic intolerance and postural tachycardia syndrome as suspected adverse effects of vaccination against human papilloma virus.

We report the characteristics of a number of patients with a syndrome of orthostatic intolerance, headache, fatigue, cognitive dysfunction, and neuropathic pain starting in close relation to HPV vaccination.
https://www.ncbi.nlm.nih.gov/pubmed/25882168


Postural Orthostatic Tachycardia With Chronic Fatigue After HPV Vaccination as Part of the “Autoimmune/Auto-inflammatory Syndrome Induced by Adjuvants”.

We report the case of a 14-year-old girl who developed postural orthostatic tachycardia syndrome (POTS) with chronic fatigue 2 months following Gardasil vaccination.
http://journals.sagepub.com/doi/full/10.1177/2324709614527812


HPV vaccination syndrome. A questionnaire-based study. 

“..93% of patients continue to have incapacitating symptoms and remain unable to attend school or work. In conclusion, a disabling syndrome of chronic neuropathic pain, fatigue, and autonomic dysfunction may appear after HPV vaccination.”
https://www.ncbi.nlm.nih.gov/m/pubmed/26354426/


Neurologic Complications in HPV Vaccination.

Delayed manifestation of cognitive dysfunction in the post-vaccinated girls…symptoms include memory loss and difficulty in reading textbooks and/or calculation.
https://www.ncbi.nlm.nih.gov/m/pubmed/26160812/


Human papilloma virus vaccine and primary ovarian failure: another facet of the autoimmune/inflammatory syndrome induced by adjuvants.

All patients developed secondary amenorrhea following HPV vaccinations, which did not resolve upon treatment with hormone replacement therapies. All patients experienced a range of common non-specific post-vaccine symptoms including nausea, headache, sleep disturbances, arthralgia and a range of cognitive and psychiatric disturbances.
http://onlinelibrary.wiley.com/doi/10.1111/aji.12151/abstract;jsessionid=13287A8D879C77263E43A6843711D444.f03t01


Autoimmune hepatitis type 2 following anti-papillomavirus vaccination in a 11-year-old girl

Here we report the case of an 11-year-old girl who developed autoimmune hepatitis type II after four weeks from vaccination against human papillomavirus.
https://www.sciencedirect.com/science/article/pii/S0264410X11006955?via%3Dihub


Cervical cancers after human papillomavirus vaccination

However, to date, there is no definite evidence showing the vaccine reduces the incidence of invasive cervical carcinoma.”
www.ncbi.nlm.nih.gov/pubmed/19155953

Increased incidence of cervical cancer in Sweden: Possible link with HPV vaccination

A time relationship exists between the start of vaccination and the increase in the incidence of cervical cancer.
http://ijme.in/wp-content/uploads/2018/04/20180430


Pancreatitis after human papillomavirus vaccination: a matter of molecular mimicry.

A 20-year-old man developed severe abdominal pain 1 week after being vaccinated with the first dose of quadrivalent human papillomavirus (HPV) vaccine (Gardasil®). Despite ongoing symptoms of nausea and pain, he received the second dose of the vaccine. Only 10 days later, laboratory results revealed significantly elevated pancreatic enzymes, and with concomitant abdominal pain and vomiting, he was diagnosed with acute pancreatitis. This case of acute pancreatitis after HPV vaccination is not a novel entity.
https://www.ncbi.nlm.nih.gov/m/pubmed/27421720/


Human papillomavirus vaccine and systemic lupus erythematosus.

In the current study, a temporal association between immunization with HPV vaccine and the appearance of a spectrum of SLE-like conditions is reported.
https://www.ncbi.nlm.nih.gov/m/pubmed/23624585/


Vaccinations and secondary immune thrombocytopenia with antiphospholipid antibodies by human papillomavirus vaccine.

A 13-year-old girl developed immune thrombocytopenic purpura (ITP) and concomitant positive antiphospholipid antibodies (aPL) following vaccination with a quadrivalent human papillomavirus (HPV) vaccine.
https://www.ncbi.nlm.nih.gov/m/pubmed/27312165/


Is Chronic Fatigue Syndrome/Myalgic Encephalomyelitis a Relevant Diagnosis in Patients with Suspected Side Effects to Human Papilloma Virus Vaccine?

The patients were referred due to orthostatic intolerance and symptoms compatible with autonomic dysfunction occurring in a close temporal association to vaccination with the Q-HPV vaccine. We found that 34 (87%) and 35(90%) of the patients fulfilled the diagnostic criteria for CFS/ME regarding to the Canadian and the IOM (Institute of Medicine) criteria respectively and suggest that CFS/ME may be a suitable diagnosis for patients with severe and persistent suspected side effects to the Q-HPV vaccine.
http://medcraveonline.com/IJVV/IJVV-01-00003.pdf


Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil.

It appears that Gardasil via its Al adjuvant and HPV antigens has the ability to trigger neuroinflammation and autoimmune reactions, further leading to behavioral changes.
https://www.ncbi.nlm.nih.gov/m/pubmed/27421722/


Severe somatoform and dysautonomic syndromes after HPV vaccination: case series and review of literature.

HPV vaccine, through its adjuvant component, is speculated to induce an abnormal activation of the immune system, involving glia cells in the nervous system too.
https://www.ncbi.nlm.nih.gov/m/pubmed/27503625/


A link between human papilloma virus vaccination and primary ovarian insufficiency: current analysis.

An increasing number of cases of POI post-HPV4 are being reported. Possible mechanisms for the suspected effect of HPV on female reproductive function are a toxic effect or an autoimmune response. The trigger could be the vaccine immunogen contents or the adjuvants, the latter are used to increase the immune reaction. The adjuvant in HPV4 contains aluminum. Animal models have shown aluminum exposure to inhibit expression of female reproductive hormones and to induce histologic changes in the ovaries.
https://www.ncbi.nlm.nih.gov/m/pubmed/26125978/


On the relationship between human papilloma virus vaccine and autoimmune diseases.

Along with the introduction of the HPV vaccines, several cases of onset or exacerbations of autoimmune diseases following the vaccine shot have been reported in the literature and pharmacovigilance databases, triggering concerns about its safety.
https://www.ncbi.nlm.nih.gov/m/pubmed/24468416/


New Concerns about the Human Papillomavirus Vaccine

The overwhelming majority (76%) of VAERS reports since 2006 with ovarian failure, premature menopause, and/or amenorrhea are associated solely with Gardasil®. When VAERS reports since 2006 are restricted to cases in which amenorrhea occurred for at least 4 months and is not associated with other known causes like polycystic ovary syndrome or pregnancy, 86/89 cases are associated with Gardasil®, 3/89 with CervarixTM, and 0/89 with other vaccines administered independently of an HPV vaccine
http://www.acpeds.org/the-college-speaks/position-statements/health-issues/new-concerns-about-the-human-papillomavirus-vaccine


Peripheral Sympathetic Nerve Dysfunction in Adolescent Japanese Girls Following Immunization with the Human Papillomavirus Vaccine.

https://www.ncbi.nlm.nih.gov/m/pubmed/26234248


Acute Disseminated Encephalomyelitis Following Immunization with Human Papillomavirus Vaccines

Vaccines can induce experimental allergic encephalitis (EAE), probably due to the molecular mimicry between the vaccine epitope and neural antigens with the subsequent activation of cross-reactive immune cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140852/


Adolescent Premature Ovarian Insufficiency Following Human Papillomavirus Vaccination: A Case Series Seen in General Practice

Three young women who developed premature ovarian insufficiency following quadrivalent human papillomavirus (HPV) vaccination. 
https://www.ncbi.nlm.nih.gov/m/pubmed/26425627/


Ampiginous choroiditis following quadrivalent human papilloma virus vaccine

A 17-year-old female was referred for new-onset vision loss in both eyes 3 weeks after being vaccinated with the quadrivalent HPV vaccine.
http://bjo.bmj.com/content/94/1/137.long


Association of acute cerebellar ataxia and human papilloma virus vaccination: a case report

This temporal association strongly suggests that ACA was induced by the vaccination. [Acute cerebellar ataxia (ACA) is a disorder that occurs when the cerebellum becomes inflamed or damaged.]
https://www.ncbi.nlm.nih.gov/m/pubmed/23378179/


Bivalent HPV vaccine safety depending on subtypes of juvenile idiopathic arthritis

15-year-old JIA ( juvenile idiopathic arthritis) patient who developed severe pain and walking disability after injection of the bivalent HPV vaccine.
http://ard.bmj.com/content/73/12/e75.long


Brachial plexus neuritis following HPV vaccination

19-year-old girl who developed a left brachial plexus neuritis following vaccination with a quadrivalent human papillomavirus (HPV) vaccine.
https://www.ncbi.nlm.nih.gov/m/pubmed/18602437/


A case-control study of quadrivalent human papillomavirus vaccine-associated autoimmune adverse events

It was observed that cases with the SAAE (serious autoimmune adverse events) outcomes were significantly more likely than controls to have received HPV4 vaccine
https://www.ncbi.nlm.nih.gov/m/pubmed/25535199/


CNS demyelination and quadrivalent HPV vaccination

We report five patients who presented with multifocal or atypical demyelinating syndromes within 21 days of immunization with the quadrivalent human papilloma virus (HPV) vaccine.
https://www.ncbi.nlm.nih.gov/m/pubmed/18805844/


Demyelinating disease and polyvalent human papilloma virus vaccination

A 19-year-old woman received two doses of Gardasil, 3 months apart, and approximately 1 month after the second dose, she developed numbness to the right foot that within 1 day extended to the contralateral foot and was associated with mid-thoracic back pain.
http://jnnp.bmj.com/content/82/11/1296.long


Demyelinating disease and vaccination of the human papillomavirus

Have been described seizures, autoimmune disorders such as Guillain-Barre syndrome, transverse myelitis, or motor neuron disease, probably adverse effects following immunization by HPV vaccine.
https://www.ncbi.nlm.nih.gov/m/pubmed/21425100/


Development of unilateral cervical and supraclavicular lymphadenopathy after human papilloma virus vaccination

A 26-year-old woman developed significant unilateral anterior cervical and supraclavicular lymphadenopathy 3 days after receiving her first dose (of a total of three doses) of human papilloma virus (HPV) vaccine.
https://www.ncbi.nlm.nih.gov/m/pubmed/18752390/


Erythema multiforme following vaccination for human papillomavirus

Vaccinations have been reported as a triggering factor, and they may be a frequent cause of EM (Erythema multiforme) in childhood.
https://www.ncbi.nlm.nih.gov/m/pubmed/19887766/


Fibromyalgia-Like Illness in 2 Girls After Human Papillomavirus Vaccination
https://www.ncbi.nlm.nih.gov/pubmed/25275771


HPV-negative Gastric Type Adenocarcinoma In Situ of the Cervix: A Spectrum of Rare Lesions Exhibiting Gastric and Intestinal Differentiation

The introduction of HPV vaccination will result in a relative increase in incidence of premalignant and malignant cervical glandular lesions exhibiting gastric differentiation and these will not be detected by HPV-based screening programs.
https://www.ncbi.nlm.nih.gov/pubmed/28394803


Human papillomavirus (HPV) vaccines as an option for preventing cervical malignancies: (how) effective and safe?

Clinical trials data have not demonstrated to date that the vaccines have actually prevented a single case of cervical cancer.
https://www.ncbi.nlm.nih.gov/m/pubmed/23016780/


Human papilloma virus vaccine associated uveitis

Possible bilateral uveitis and papillitis following HPV vaccination.
https://www.ncbi.nlm.nih.gov/m/pubmed/24191906/


Hypersensitivity reactions to human papillomavirus vaccine in Australian schoolgirls: retrospective cohort study

Twenty three (92%) experienced reactions after the first dose. Thirteen (52%) experienced urticaria or angio-oedema, and of these, two experienced anaphylaxis. Thirteen had generalised rash, one with angio-oedema. The median time to reaction was 90 minutes.
https://www.ncbi.nlm.nih.gov/m/pubmed/19050332/


Hypothesis: Human papillomavirus vaccination syndrome–small fiber neuropathy and dysautonomia could be its underlying pathogenesis

Development of complex regional pain syndrome (CRPS), postural orthostatic tachycardia syndrome (POTS), and fibromyalgia after HPV vaccination.
https://www.ncbi.nlm.nih.gov/m/pubmed/25990003/


Immune thrombocytopenic purpura following human papillomavirus vaccination
https://www.ncbi.nlm.nih.gov/m/pubmed/19464550/


Kikuchi-Fujimoto disease following vaccination against human papilloma virus infection and Japanese encephalitis

We present a 14-year-old girl who suffered from fever and cervical lymph node swelling following simultaneous administration of human papilloma virus vaccine and Japanese encephalitis virus vaccine.
https://www.ncbi.nlm.nih.gov/m/pubmed/22476507/


Lichenoid Drug Eruption After Human Papillomavirus Vaccination

This case report is the first of a lichenoid drug eruption in a child after human papillomavirus vaccination.
http://onlinelibrary.wiley.com/doi/10.1111/pde.12516/full


Pancreatitis following human papillomavirus vaccination
https://www.ncbi.nlm.nih.gov/pubmed/18673112


Panuveitis With Exudative Retinal Detachments After Vaccination Against Human Papilloma Virus

A 20-year-old white woman presented with bilateral acute visual loss, panuveitis, and exudative retinal detachments 3 weeks after a second dose of quadrivalent human papillomavirus (HPV4) vaccine.
https://www.ncbi.nlm.nih.gov/m/pubmed/26469238/


Pharmaceutical Companies’ Role in State Vaccination Policymaking: The Case of Human Papillomavirus Vaccination

Merck promoted school-entry mandate legislation by serving as an information resource, lobbying legislators, drafting legislation, mobilizing female legislators and physician organizations, conducting consumer marketing campaigns, and filling gaps in access to the vaccine.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483914/


Potential cross-reactivity between HPV16 L1 protein and sudden death-associated antigens

In exploring the primary sequence of the human papilloma virus (HPV) 16 major capsid L1 protein for peptide sharing with human proteins, we find that 34 pentamers from the viral capsid protein are shared with human proteins that, when altered, have been linked to short QT syndrome, arrhythmogenic cardiac disorders, cardiovascular diseases and sudden death.
https://www.ncbi.nlm.nih.gov/m/pubmed/21699023/


Premature ovarian failure 3 years after menarche in a 16-year-old girl following human papillomavirus vaccination

Premature ovarian failure was then notified as a possible adverse event following this vaccination.
https://www.ncbi.nlm.nih.gov/m/pubmed/23035167/


Severe manifestations of autoimmune syndrome induced by adjuvants (Shoenfeld’s syndrome).

The majority of severe ASIA (Autoimmune/inflammatory syndrome induced by adjuvants) cases were related to HPV vaccine, silicone, influenza vaccine and mineral oil injections. The interval from exposition to severe manifestation was from 2 days to 23 years.
https://www.ncbi.nlm.nih.gov/m/pubmed/27412294/


A 16-year-old girl with bilateral visual loss and left hemiparesis following an immunization against human papilloma virus

We report the course of a 16-year-old girl who presented with near complete visual loss in association with a recent immunization against human papilloma virus.
https://www.ncbi.nlm.nih.gov/m/pubmed/20189933/


Small Fiber Neuropathy Following Vaccination

This case report describes an acute onset of non-length-dependent SFN (small fiber neuropathy) potentially related to human papillomavirus vaccine administration
https://www.ncbi.nlm.nih.gov/m/pubmed/27552388/


Syncope and seizures following human papillomavirus vaccination: a retrospective case series

Syncope and syncopal seizures occurred after 4vHPV vaccination
https://www.ncbi.nlm.nih.gov/m/pubmed/21449862/


Telogen effluvium following bivalent human papillomavirus vaccine administration: a report of two cases

The two children began to lose their hair following the second HPV vaccine dose.
https://www.ncbi.nlm.nih.gov/m/pubmed/22584489/


Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus

We herein present two cases of acute disseminated encephalomyelitis (ADEM) following vaccination against human papilloma virus (HPV).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140871/


Two unclear cases of death. Can we still recommend HPV vaccination?
https://www.ncbi.nlm.nih.gov/m/pubmed/18361151/


An unmasking phenomenon in an observational post-licensure safety study of adolescent girls and young women

Of the 18 confirmed cases of Graves’ disease diagnosed in days 1-60 following vaccination, only 6 cases appeared to be truly new onset.
https://www.ncbi.nlm.nih.gov/m/pubmed/22580356/


Vaccine-related serious adverse events might have been under-recognized in the pivotal HPV vaccine randomized trial

The innovative nine-valent HPV dose has more than double HPV virus-like particles and aluminum adjuvant than the previous formulation.
http://link.springer.com/article/10.1007%2Fs10067-017-3575-z


SIDE EFFECTS IN YOUNG GIRLS TAKE GARDASIL OUT FROM JAPANESE MARKET

The Japanese government stopped giving the Gardasil vaccine in 2013 after health officials recorded nearly 2,000 adverse reactions, according to the Tokyo Times.

http://www.tokyotimes.com/side-effects-in-young-girls-take…/


Gardasil Researcher Speaks Out

There is the MIT and Stanford educated medical doctor who also has a Master’s Degree in Public Health? The one who is a vaccine developer and has worked for Merck, the manufacturers of the Gardasil vaccine? Dr. Harper has repeatedly spoken out against the HPV vaccine and raised serious concerns about whether it is safe. As reported by CBS News in 2009.
http://www.cbsnews.com/news/gardasil-researcher-speaks-out/


UK Association of HPV Vaccine Injured Daughters (AHVID)

The thousands of parents who belong to this non-profit, the parents who followed their doctor’s orders and got the “cervical cancer jab,” as they like to call it in the U.K.
http://sanevax.org/uk-association-of-hpv-vaccine-injured-d…/


A lowered probability of pregnancy in females in the USA aged 25–29 who received a human papillomavirus vaccine injection

“Results suggest that females who received the HPV shot were less likely to have ever been pregnant than women in the same age group who did not receive the shot. If 100% of females in this study had received the HPV vaccine, data suggest the number of women having ever conceived would have fallen by 2 million. Further study into the influence of HPV vaccine on fertility is thus warranted.”
https://www.tandfonline.com/doi/abs/10.1080/15287394.2018.1477640?journalCode=uteh20&


Serious adverse events after HPV vaccination: a critical review of randomized trials and post-marketing case series

“Scrutiny of two of the largest randomized trials unveiled significantly more serious adverse events in the investigated HPV vaccine arm of the study.”
https://link.springer.com/article/10.1007%2Fs10067-017-3768-5

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