Acute fulminant myocarditis after diphtheria, polio, and tetanus vaccination.
“We report an infant case of acute fulminant myocarditis which occurred after administration of a diphtheria, polio, and tetanus vaccination. Fever and dyspnea developed after the vaccination. Extracorporeal membrane oxygenation was used for intractable cardiogenic shock. The patient survived the extracorporeal support, but poor ventricular contractility recurred 2 months later and she died while waiting for heart transplantation.” Asian Cardiovascular and Thoracic Annals 2006
Acute myopericarditis after multiple vaccinations in an adolescent: case report and review of the literature.
“We report a case of postvaccination acute myopericarditis in an adolescent. The patient presented with acute chest pain, diffuse ST-segment elevation, and elevated cardiac enzyme levels. Cardiac MRI was consistent with acute myocarditis. He recovered within a few days with nonsteroidal antiinflammatory treatment and remains clinically stable, with improvement of MRI findings at the 10-week follow-up. Postvaccination cases of myopericarditis reported in the pediatric literature are also reviewed.” Pediatrics 2007
Adverse events following vaccination in premature infants.
“CONCLUSION: Vaccine-related cardiorespiratory events are relatively common in preterm babies. Problems were much more common if vaccine is administered at or before 70 d. These babies should therefore be monitored postvaccination. Further prospective studies are needed to clarify whether delaying vaccination offers protection against these adverse events.” Acta Paediatrica 2001
Apnea after immunization of preterm infants.
“However, 12 (12%) infants experienced a recurrence of apnea, and 11 (11%) had at least a 50% increase in the number of apneic and bradycardic episodes in the 72 hours after immunization.” Journal of Pediatrics 1997
A case of sudden death after Japanese encephalitis vaccination.
Japanese encephalitis (JE) virus is estimated to result in 3500-50,000 clinical cases every year, with mortality rates of up to 20-50% and a high percentage of neurological sequelae in survivors. Vaccination is the single most important measure in preventing this disease. Legal Medicine (Tokyo) 2015
Chest pain, ST elevation, and positive cardiac enzymes in an austere environment: differentiating smallpox vaccination-mediated myocarditis and acute coronary syndrome in Operation Iraqi Freedom.
Myocarditis is a recognized but rare complication of smallpox immunization. It typically presents within 30 days of immunization and on initial presentation shares many characteristics with acute coronary syndrome. Electrocardiogram findings, elevated cardiac enzymes, and undifferentiated chest pain require immediate implementation of therapy directed towards an acute coronary syndrome. In an austere environment, access to advanced care may be limited. Emergency Medicine Journal 2012
Identifying birth defects in automated data sources in the Vaccine Safety Datalink. 2017
“Cardiac defects were most common (65.4 per 10 000 live births), with one-fourth classified as severe, requiring emergent intervention.” Pharmacoepidemiology and Drug Safety 2017 https://www.ncbi.nlm.nih.gov/m/pubmed/28054412/
Incidence of apnoea and bradycardia in preterm infants following triple antigen immunization.
“Ninety-seven preterm infants were immunized with diphtheria-tetanus-pertussis (DTP) prior to discharge from hospital. The mean gestational age at birth was 28.1 weeks (range 24-34) and the mean age at immunization was 80.6 days (range 44-257). Nineteen (20%) infants developed apnoea or bradycardia within 24 h of immunization.” Journal of Paediatrics and Child Health 1994 https://www.ncbi.nlm.nih.gov/m/pubmed/7865269/
Inflammation-related effects of adjuvant influenza A vaccination on platelet activation and cardiac autonomic function.
Together with an inflammatory reaction, influenza A vaccine induced platelet activation and sympathovagal imbalance towards adrenergic predominance. Significant correlations were found between CRP levels and HRV parameters, suggesting a pathophysiological link between inflammation and cardiac autonomic regulation. The vaccine-related platelet activation and cardiac autonomic dysfunction may transiently increase the risk of cardiovascular events. Journal of Internal Medicine 2011
Possible predictors of cardiorespiratory events after immunization in preterm neonates.
“BACKGROUND: The influence of the first immunization on cardiorespiratory (CR) stability in very preterm infants is still a controversial subject.” Neonatology 2013
Potential cross-reactivity between HPV16 L1 protein and sudden death-associated antigens.
“In exploring the primary sequence of the human papilloma virus (HPV) 16 major capsid L1 protein for peptide sharing with human proteins, we find that 34 pentamers from the viral capsid protein are shared with human proteins that, when altered, have been linked to short QT syndrome, arrhythmogenic cardiac disorders, cardiovascular diseases and sudden death.” Journal of Experimental Therapeutics and Oncology 2011
Recurrence of cardiorespiratory events following repeat DTaP-based combined immunization in very low birth weight premature infants.
“We evaluated the tolerance to immunization of 64 very low birth weight preterm infants. Thirty-three of the infants experienced a cardiorespiratory event after the first vaccination, and 6 of these 33 (18%) had a recurrence after the second vaccination, including 2 infants previously discharged to home. A cardiorespiratory event associated with the first vaccination was the sole risk factor for recurrence identified.” Journal of Pediatrics 2008
A report of 2 cases of myopericarditis after Vaccinia virus (smallpox) immunization.
“CONCLUSION: Myopericarditis should be suspected when patients with recent history of smallpox vaccination present with chest pain or shortness of breath. Nonsteroidal anti-inflammatory drugs are useful in the management of post-vaccinial myopericarditis.” MWJ 2011