Chronic fatigue syndrome and fibromyalgia following immunization with the hepatitis B vaccine: another angle of the ‘autoimmune (auto-inflammatory) syndrome induced by adjuvants’ (ASIA).

The objectives of this study were to gather information regarding demographic and clinical characteristics of patients diagnosed with either fibromyalgia (FM) or chronic fatigue (CFS) following hepatitis B vaccination (HBVv) and furthermore to apply the recently suggested criteria of autoimmune (auto-inflammatory) syndromes induced by adjuvants (ASIA), in the aim of identifying common characteristics that may suggest an association between fibromyalgia, chronic fatigue and HBV vaccination. Immunology Research 2014
https://www.ncbi.nlm.nih.gov/m/pubmed/25427994


Etiology of fibromyalgia: the possible role of infection and vaccination.

“Fibromyalgia syndrome (FMS), a condition characterized by widespread pain and diffuse tenderness, is considered a multifactorial disorder. FMS is now recognized as one of the “central” pain syndromes. Environmental and genetic factors play a role in the pathogenesis of FMS. Various triggers including trauma and stress as well as infections, may precipitate the development of FMS. Certain infections including hepatitis C virus, HIV and Lyme disease have been temporally associated with the development of FMS. There is some evidence for the possible role of vaccinations in triggering the development of FMS and related syndromes, however this association remains to be established.” Autoimmun review 2008
https://www.ncbi.nlm.nih.gov/m/pubmed/18706528


Fibromyalgia, infection and vaccination: two more parts in the etiological puzzle.

“Based on this example a model is proposed, wherein vaccinations function as co-triggers for the development of functional disorders including fibromyalgia, in conjunction with additional contributing factors.” Autoimmunity 2006
https://www.ncbi.nlm.nih.gov/m/pubmed/17071055


HPV vaccination syndrome. A questionnaire-based study.

“..93% of patients continue to have incapacitating symptoms and remain unable to attend school or work. In conclusion, a disabling syndrome of chronic neuropathic pain, fatigue, and autonomic dysfunction may appear after HPV vaccination.” Clinical Rheumatology 2015
https://www.ncbi.nlm.nih.gov/m/pubmed/26354426


Undifferentiated connective tissue disease, fibromyalgia and the environmental factors. 2017

“UCTD exposed to major ASIA triggers (vaccines, silicone) displayed typical features of ASIA (general weakness, chronic fatigue, irritable bowel syndrome) in the context of a predisposing genetic background (familiarity for autoimmunity).” Current Opinion in Rheumatology 2017
https://www.ncbi.nlm.nih.gov/m/pubmed/28368979


Chronic fatigue syndrome with autoantibodies–the result of an augmented adjuvant effect of hepatitis-B vaccine and silicone implant.

https://www.ncbi.nlm.nih.gov/m/pubmed/18725327/


Hypothesis: Human papillomavirus vaccination syndrome–small fiber neuropathy and dysautonomia could be its underlying pathogenesis.

“However, seemingly inexplicit adverse reactions have been described after the injection of the newer vaccines vs. human papillomavirus (HPV). The symptoms more often reported are chronic pain with paresthesias, headaches, fatigue, and orthostatic intolerance. Adverse reactions appear to be more frequent after HPV vaccination when compared to other type of immunizations.” Clinical Rheumatology 2015 https://www.ncbi.nlm.nih.gov/m/pubmed/25990003/


Metal-induced inflammation triggers fibromyalgia in metal-allergic patients

“CONCLUSION: Metal allergy is frequent in FM patients. The reduction of metal exposure resulted in improved health in the majority of metal-sensitized patients. This suggests that metal-induced inflammation might be an important risk factor in a subset of patients with FM.” Neuro Endocrinology Letters 2013
https://www.ncbi.nlm.nih.gov/m/pubmed/24378456/

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