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Vaccine Ingredients

Here is the list of vaccine ingredients per the CDC website. This table includes not only vaccine ingredients (e.g., adjuvants and preservatives), but also substances used during the manufacturing process, including vaccine-production media, that are removed from the final product and present only in trace quantities.

Source: CDC.gov

 

VACCINE EXCIPIENT & MEDIA SUMMARY

Vaccine Contains Source:
Manufacturer’s P.I. Dated
Adenovirus sucrose, D-mannose, D-fructose, dextrose, potassium phosphate, plasdone C, anhydrous lactose, micro crystalline cellulose, polacrilin potassium, magnesium stearate, cellulose acetate phthalate, alcohol, acetone, castor oil, FD&C Yellow #6 aluminum lake dye, human serum albumin, fetal bovine serum, sodium bicarbonate, human-diploid fibroblast cell cultures (WI-38), Dulbecco’s Modified Eagle’s Medium, monosodium glutamate March 2011
Anthrax (Biothrax) aluminum hydroxide, benzethonium chloride, formaldehyde, amino acids, vitamins, inorganic salts and sugars May 2012
BCG (Tice) glycerin, asparagine, citric acid, potassium phosphate, magnesium sulfate, Iron ammonium citrate, lactose February 2009
DT (Sanofi) aluminum potassium sulfate, peptone, bovine extract, formaldehyde, thimerosal (trace), modified Mueller and Miller medium, ammonium sulfate December 2005
DTaP (Daptacel) aluminum phosphate, formaldehyde, glutaraldehyde, 2-Phenoxyethanol, Stainer-Scholte medium, modified Mueller’s growth medium, modified Mueller-Miller casamino acid medium (without beef heart infusion), dimethyl 1-beta-cyclodextrin, ammonium sulfate October 2013
DTaP (Infanrix) formaldehyde, glutaraldehyde, aluminum hydroxide, polysorbate 80, Fenton medium (containing bovine extract), modified Latham medium (derived from bovine casein), modified Stainer-Scholte liquid medium November 2013
DTaP-IPV (Kinrix) formaldehyde, glutaraldehyde, aluminum hydroxide, Vero (monkey kidney) cells, calf serum, lactalbumin hydrolysate, polysorbate 80, neomycin sulfate, polymyxin B, Fenton medium (containing bovine extract), modified Latham medium (derived from bovine casein), modified Stainer-Scholte liquid medium November 2013
DTaP-HepB-IPV (Pediarix) formaldehyde, gluteraldehyde, aluminum hydroxide, aluminum phosphate, lactalbumin hydrolysate, polysorbate 80, neomycin sulfate, polymyxin B, yeast protein, calf serum, Fenton medium (containing bovine extract), modified Latham medium (derived from bovine casein), modified Stainer-Scholte liquid medium, Vero (monkey kidney) cells November 2013
DTaP-IPV/Hib (Pentacel) aluminum phosphate, polysorbate 80, formaldehyde, sucrose, gutaraldehyde, bovine serum albumin, 2-phenoxethanol, neomycin, polymyxin B sulfate, Mueller’s Growth Medium, Mueller-Miller casamino acid medium (without beef heart infusion), Stainer-Scholte medium (modified by the addition of casamino acids and dimethyl-beta- cyclodextrin), MRC-5 (human diploid) cells, CMRL 1969 medium (supplemented with calf serum), ammonium sulfate, and medium 199 October 2013
Hib (ActHIB) ammonium sulfate, formalin, sucrose, Modified Mueller and Miller medium January 2014
Hib (Hiberix) formaldehyde, lactose, semi-synthetic medium March 2012
Hib (PedvaxHIB) aluminum hydroxphosphate sulfate, ethanol, enzymes, phenol, detergent, complex fermentation medium December 2010
Hib/Hep B (Comvax) yeast (vaccine contains no detectable yeast DNA), nicotinamide adenine dinucleotide, hemin chloride, soy peptone, dextrose, mineral salts, amino acids, formaldehyde, potassium aluminum sulfate, amorphous aluminum hydroxyphosphate sulfate, sodium borate, phenol, ethanol, enzymes, detergent December 2010
Hib/Mening. CY (MenHibrix) tris (trometamol)-HCl, sucrose, formaldehyde, synthetic medium, semi- synthetic medium 2012
Hep A (Havrix) aluminum hydroxide, amino acid supplement, polysorbate 20, formalin, neomycin sulfate, MRC-5 cellular proteins December 2013
Hep A (Vaqta) amorphous aluminum hydroxyphosphate sulfate, bovine albumin, formaldehyde, neomycin, sodium borate, MRC-5 (human diploid) cells February 2014
Hep B (Engerix-B) aluminum hydroxide, yeast protein, phosphate buffers, sodium dihydrogen phosphate dihydrate December 2013
Hep B (Recombivax) yeast protein, soy peptone, dextrose, amino acids, mineral salts, potassium aluminum sulfate, amorphous aluminum hydroxyphosphate sulfate, formaldehyde, phosphate buffer May 2014
Hep A/Hep B (Twinrix) formalin, yeast protein, aluminum phosphate, aluminum hydroxide, amino acids, phosphate buffer, polysorbate 20, neomycin sulfate, MRC-5 human diploid cells August 2012
Human Papillomavirus (HPV) (Cerverix) vitamins, amino acids, lipids, mineral salts, aluminum hydroxide, sodium dihydrogen phosphate dehydrate, 3-O-desacyl-4’ Monophosphoryl lipid A, insect cell, bacterial, and viral protein November 2013
Human Papillomavirus (HPV) (Gardasil) yeast protein, vitamins, amino acids, mineral salts, carbohydrates, amorphous aluminum hydroxyphosphate sulfate, L-histidine, polysorbate 80, sodium borate June 2014
Human Papillomavirus (HPV) (Gardasil 9) yeast protein, vitamins, amino acids, mineral salts, carbohydrates, amorphous aluminum hydroxyphosphate sulfate, L-histidine, polysorbate 80, sodium borate December 2014
Influenza (Afluria) beta-propiolactone, thimerosol (multi-dose vials only), monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, neomycin sulfate, polymyxin B, egg protein, sucrose December 2013
Influenza (Agriflu) egg proteins, formaldehyde, polysorbate 80, cetyltrimethylammonium bromide, neomycin sulfate, kanamycin, barium 2013
Influenza (Fluarix) Trivalent and Quadrivalent octoxynol-10 (Triton X- Į-tocopheryl hydrogen succinate, polysorbate 80 (Tween 80), hydrocortisone, gentamicin sulfate, ovalbumin, formaldehyde, sodium deoxycholate, sucrose, phosphate buffer June 2014
Influenza (Flublok) monobasic sodium phosphate, dibasic sodium phosphate, polysorbate 20, baculovirus and host cell proteins, baculovirus and cellular DNA, Triton X-100, lipids, vitamins, amino acids, mineral salts March 2014
Influenza (Flucelvax) Madin Darby Canine Kidney (MDCK) cell protein, MDCK cell DNA, SRO\VRUEDWHFHW\OWULPHWKO\DPPRQLXPEURPLGHȕ-propiolactone, phosphate buffer March 2014
Influenza (Fluvirin) nonylphenol ethoxylate, thimerosal (multidose vial–trace only in prefilled syringe), polymyxin, neomycin, beta-propiolactone, egg proteins, phosphate buffer February 2014
Influenza (Flulaval) Trivalent and Quadrivalent thimerosal, formaldehyde, sodium deoxycholate, egg proteins, phosphate buffer February 2013
Influenza (Fluzone: Standard (Trivalent and Quadrivalent), High-Dose, & Intradermal) formaldehyde, octylphenol ethoxylate (Triton X-100), gelatin (standard trivalent formulation only), thimerosal (multi-dose vial only) , egg protein, phosphate buffers, sucrose 2014
Influenza (FluMist) Quadrivalent ethylene diamine tetraacetic acid (EDTA), monosodium glutamate, hydrolyzed porcine gelatin, arginine, sucrose, dibasic potassium phosphate, monobasic potassium phosphate, gentamicin sulfate, egg protein July 2013
Japanese Encephalitis (Ixiaro) aluminum hydroxide, Vero cells, protamine sulfate, formaldehyde, bovine serum albumin, sodium metabisulphite, sucrose May 2013
Meningococcal (MCV4- Menactra) formaldehyde, phosphate buffers, Mueller Hinton agar, Watson Scherp media, Modified Mueller and Miller medium, detergent, alcohol, ammonium sulfate April 2013
Meningococcal (MCV4- Menveo) formaldehyde, amino acids, yeast extract, Franz complete medium, CY medium August 2013
Meningococcal (MPSV4- Menomune) thimerosal (multi-dose vial only), lactose, Mueller Hinton casein agar, Watson Scherp media, detergent, alcohol April 2013
Meningococcal (MenB – Bexsero) aluminum hydroxide, E. coli, histidine, sucrose, deoxycholate, kanomycin 2015
Meningococcal (MenB – Trumenba) polysorbate 80, histodine, E. coli, fermentation growth media October 2015
MMR (MMR-II) Medium 199 (vitamins, amino acids, fetal bovine serum, sucrose, glutamate) , Minimum Essential Medium, phosphate, recombinant human albumin, neomycin, sorbitol, hydrolyzed gelatin, chick embryo cell culture, WI-38 human diploid lung fibroblasts June 2014
MMRV (ProQuad) sucrose, hydrolyzed gelatin, sorbitol, monosodium L-glutamate, sodium phosphate dibasic, human albumin, sodium bicarbonate, potassium phosphate monobasic, potassium chloride, potassium phosphate dibasic, neomycin, bovine calf serum, chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells March 2014
Pneumococcal (PCV13 – Prevnar 13) casamino acids, yeast, ammonium sulfate, Polysorbate 80, succinate buffer, aluminum phosphate, soy peptone broth January 2014
Pneumococcal (PPSV-23 – Pneumovax) phenol May 2014
Polio (IPV – Ipol) 2-phenoxyethanol, formaldehyde, neomycin, streptomycin, polymyxin B, monkey kidney cells, Eagle MEM modified medium, calf serum protein, Medium 199 May 2013
Rabies (Imovax) Human albumin, neomycin sulfate, phenol red indicator, MRC-5 human diploid cells, beta-propriolactone April 2013
Rabies (RabAvert) ȕ-propiolactone, potassium glutamate, chicken protein, egg protein, neomycin, chlortetracycline, amphotericin B, human serum albumin, polygeline (processed bovine gelatin), sodium EDTA, bovine serum March 2012
Rotavirus (RotaTeq) sucrose, sodium citrate, sodium phosphate monobasic monohydrate, sodium hydroxide, polysorbate 80, cell culture media, fetal bovine serum, vero cells [DNA from porcine circoviruses (PCV) 1 and 2 has been detected in RotaTeq. PCV-1 and PCV-2 are not known to cause disease in humans.] June 2013
Rotavirus (Rotarix) amino acids, dextran, sorbitol, sucrose, calcium carbonate, xanthan, Dulbecco’s Modified Eagle Medium (potassium chloride, magnesium sulfate, ferric (III) nitrate, sodium phosphate, sodium pyruvate, D- glucose, concentrated vitamin solution, L-cystine, L-tyrosine, amino acids solution, L-glutamine, calcium chloride, sodium hydrogenocarbonate, and phenol red) [Porcine circovirus type 1 (PCV-1) is present in Rotarix. PCV-1 is not known to cause disease in humans.] May 2014
Smallpox (Vaccinia – ACAM2000) human serum albumin, mannitol, neomycin, glycerin, polymyxin B, phenol, Vero cells, HEPES September 2009
Td (Decavac) aluminum potassium sulfate, peptone, formaldehyde, thimerosal, bovine muscle tissue (US sourced), Mueller and Miller medium, ammonium sulfate March 2011
Td (Tenivac) aluminum phosphate, formaldehyde, modified Mueller-Miller casamino acid medium without beef heart infusion, ammonium sulfate April 2013
Td (Mass Biologics) aluminum phosphate, formaldehyde, thimerosal (trace), ammonium phosphate, modified Mueller’s media (containing bovine extracts) February 2011
Tdap (Adacel) aluminum phosphate, formaldehyde, glutaraldehyde, 2-phenoxyethanol, ammonium sulfate, Stainer-Scholte medium, dimethyl-beta-cyclodextrin, modified Mueller’s growth medium, Mueller-Miller casamino acid medium (without beef heart infusion) March 2014
Tdap (Boostrix) formaldehyde, glutaraldehyde, aluminum hydroxide, polysorbate 80 (Tween 80), Latham medium derived from bovine casein, Fenton medium containing a bovine extract, Stainer-Scholte liquid medium February 2013
Typhoid (inactivated – Typhim Vi) hexadecyltrimethylammonium bromide, formaldehyde, phenol, polydimethylsiloxane, disodium phosphate, monosodium phosphate, semi-synthetic medium March 2014
Typhoid (oral – Ty21a) yeast extract, casein, dextrose, galactose, sucrose, ascorbic acid, amino acids, lactose, magnesium stearate. gelatin September 2013
Varicella (Varivax) sucrose, phosphate, glutamate, gelatin, monosodium L-glutamate, sodium phosphate dibasic, potassium phosphate monobasic, potassium chloride, sodium phosphate monobasic, potassium chloride, EDTA, residual components of MRC-5 cells including DNA and protein, neomycin, fetal bovine serum, human diploid cell cultures (WI-38), embryonic guinea pig cell cultures, human embryonic lung cultures March 2014
Yellow Fever (YF-Vax) sorbitol, gelatin, egg protein May 2013
Zoster (Shingles – Zostavax) sucrose, hydrolyzed porcine gelatin, monosodium L-glutamate, sodium phosphate dibasic, potassium phosphate monobasic, neomycin, potassium chloride, residual components of MRC-5 cells including DNA and protein, bovine calf serum February 2014

A table listing vaccine excipients and media by excipient can be found in: Grabenstein JD. ImmunoFacts: Vaccines and Immunologic Drugs – 2013

(38th revision). St Louis, MO: Wolters Kluwer Health, 2012.

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