CNS demyelination and quadrivalent HPV vaccination.

Although the target population for vaccination, young females, has an inherently high risk for MS, the temporal association with demyelinating events in these cases may be explained by the potent immuno-stimulatory properties of HPV virus-like particles which comprise the vaccine.
Multiple Sclerosis Journal 2009
https://www.ncbi.nlm.nih.gov/m/pubmed/18805844


Demyelinating disease and polyvalent human papilloma virus vaccination

“Since its inception, the polyvalent vaccine against the human papilloma virus (HPV), Gardasil, has generated some controversies as a temporal relationship between the administrations of the vaccine and the development of a few autoimmune diseases, such as acute disseminated encephalomyelitis (ADEM), multiple sclerosis (MS) and Guillain–Barre syndrome have been reported.1–3 We encountered two cases whose initial presentation of CNS demyelination followed in close time relationship the administration of Gardasil vaccine and we discuss their possible association.

Case No 1

A 19-year-old woman received two doses of Gardasil, 3 months apart, and approximately 1 month after the second dose, she developed numbness to the right foot that within 1 day extended to the contralateral foot and was associated with mid-thoracic back pain. Her neurological examination was only significant for the altered perception to touch to the feet. Deep tendon reflexes were normal and plantar reflexes in flexion. MRI of cervical and thoracic spine revealed a total of three lesions with characteristic demyelinating appearance, one of those in the thoracic spine was contrast-enhancing (figure 1A–C). MRI brain demonstrated one additional white matter lesion also consistent with a demyelinating process.” BMJ 2011
http://jnnp.bmj.com/content/82/11/1296.long


Evolution of multiple sclerosis in France since the beginning of hepatitis B vaccination

“Statistical data from these latter sources seem to show a significant correlation between the number of hepatitis B vaccinations performed and the declaration to the pharmacovigilance of multiple sclerosis occurring between 1 and 2 years later. The application of the Hill’s criteria to these data indicates that the correlation between hepatitis B vaccine and multiple sclerosis may be causal.”  Immunologic Research 2014
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266455


Hepatitis B vaccination and associated oral manifestations: a non-systematic review of literature and case reports.

“After reviewing the literature, we observed that complications seen after Hepatitis B vaccination are sudden infant death syndrome, multiple sclerosis, chronic fatigue syndrome, idiopathic thrombocytopenic purpura, vasculititis optic neuritis, anaphylaxis, systemic lupus erytymatosus, lichen planus and neuro-muscular disorder.”
Annals of Medical and Health Sciences Research 2014
https://www.ncbi.nlm.nih.gov/m/pubmed/25506472


Characteristics of pediatric multiple sclerosis: The Turkish pediatric multiple sclerosis database. (2017)

“The earlier-onset group had a higher rate of infection/vaccination preceding initial attack, initial diagnosis of ADEM, longer interval between first 2 attacks, and more disability accumulating in the first 3 years of the disease.”
https://www.ncbi.nlm.nih.gov/m/pubmed/28694135/


Multiple sclerosis and hepatitis B vaccination: could minute contamination of the vaccine by partial hepatitis B virus polymerase play a role through molecular mimicry?

“Reports of multiple sclerosis developing after hepatitis B vaccination have led to the concern that this vaccine might be a cause of multiple sclerosis in previously healthy subjects.” Medical Hypotheses 2005
https://www.ncbi.nlm.nih.gov/m/pubmed/15908138/


Recombinant hepatitis B vaccine and the risk of multiple sclerosis: a prospective study

“These findings are consistent with the hypothesis that immunization with the recombinant hepatitis B vaccine is associated with an increased risk of MS, and challenge the idea that the relation between hepatitis B vaccination and risk of MS is well understood.” Neurology 2004
https://www.ncbi.nlm.nih.gov/m/pubmed/15365133/

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