Polysorbate 80: Dangerous and Toxic

WHAT IS POLYSORBATE 80?

Polysorbate 80 is a chemical used by physicians to open the blood-brain barrier, for the purpose of chemotherapy for brain cancer. The chemicals then bind tightly to the polysorbate 80 and the chemo can reach the cancer cells.

Polysorbate 80 is used in vaccines to reduce the surface tension of the chemicals, and increase the solubility of chemicals that normally would not be able to dissolve together (think oil and water). It also works as an emulsifier so the chemicals can disperse evenly upon injection.

This sounds like a smart plan, right? The problem is, it also opens the blood-brain barrier and the brain is exposed to the chemicals like aluminum (a neurotoxin), formaldehyde (embalming fluid and a carcinogen), glyphosate (another carcinogen), etc. Since it increases solubility and absorbability, it makes it incredibly easy for the brain to absorb the toxins; the toxins bind tightly to the polysorbate 80 and flow right through the blood-brain barrier to do their damage.

Not only does polysorbate 80 open up the brain to toxins, it can potentially be toxic itself. There are numerous studies linking it to infertility, anaphylactic shock, cardiac issues, cancer and even death. See the studies below.

Many of the studies on the toxicity of polysorbate 80 (also called Tween 80) only test via inhalation or ingestion versus injection. But when something is ingested, it is only 1-3% absorbed into the body because the toxin goes through our bodies natural detox filter pathway. But injected toxins go straight into the bloodstream and bypass this pathway — meaning 95+% is absorbed into body tissues. Eventually these toxins will accumulate and cause a health issue. Injection is very different from ingestion.

Studies on Polysorbate 80

Polysorbate 80 allows toxins into the brain

Polysorbate 80 also opens up the blood-brain barrier allowing toxins into the brain, which would otherwise not reach the brain.
These studies show the use of Polysorbate 80 in drug development as a means to cross the blood-brain barrier, which is there to protect us from these toxins crossing the barrier.

The Blood-Brain Barrier: Bottleneck in Brain Drug Development. NeuroRx, 2005

Preparation and Therapeutic Efficacy of Polysorbate-80-Coated Amphotericin B/PLA-b-PEG Nanoparticles. Journal of Biomaterials Science 20 (2009)

Tween 80 containing lipid nanoemulsions for delivery of indinavir to brain. Acta Pharmaceutica Sinica B, 2013

Stealth lipid polymer hybrid nanoparticles loaded with rutin for effective brain delivery – comparative study with the gold standard (Tween 80): optimization, characterization and biodistribution. Drug Delivery, 2017

Superparamagnetic Iron Oxide Nanoparticles Modified with Tween 80 Pass through the Intact Blood-Brain Barrier in Rats under Magnetic Field. ACS Applied Materials and Interfaces, 2016

Polysorbate 80 and Infertility

Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions. Annals of Allergy, Asthma and Immunology, 2005

The study included a pregnant woman who suffered anaphylactic shock after being given a IV drip of multi-vitamins containing polysorbate 80.

It is of current relevance as a ‘hidden’ inductor of anaphylactoid reactions”, and “Polysorbate 80 was identified as the causative agent for the anaphylactoid reaction of nonimmunologic origin in the patient. Conclusions: Polysorbate 80 is a ubiquitously used solubilizing agent that can cause severe nonimmunologic anaphylactoid reactions.

Delayed effects of neonatal exposure to Tween 80 on female reproductive organs in rats. Food and Chemical Toxicology, 1993

Baby female rats were injected with polysorbate 80 at days 4-7 after birth. It accelerated the maturing of the rats and caused changes to the vagina and womb lining, hormonal changes, ovary deformities and degenerative follicles.

Treatment with Tween 80 accelerated maturation, prolonged the oestrus cycle, and induced persistent vaginal oestrus. The relative weight of the uterus and ovaries was decreased relative to the untreated controls. Squamous cell metaplasia of the epithelial lining of the uterus and cytological changes in the uterus were indicative of chronic oestrogenic stimulation. Ovaries were without corpora lutea, and had degenerative follicles.

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