Current Safety Concerns with Human Papillomavirus Vaccine: A Cluster Analysis of Reports in VigiBase® (2017)

“Cluster analysis reveals additional reports of AEs following HPV vaccination that are serious in nature and describe symptoms that overlap those reported in cases from the recent safety signals (POTS, CRPS, and CFS), but which do not report explicit diagnoses. While the causal association between HPV vaccination and these AEs remains uncertain, more extensive analyses of spontaneous reports can better identify the relevant case series for thorough signal evaluation.” Drug Safety 2017
https://link.springer.com/article/10.1007/s40264-016-0456-3


HPV vaccination syndrome. A questionnaire-based study.

“..93% of patients continue to have incapacitating symptoms and remain unable to attend school or work. In conclusion, a disabling syndrome of chronic neuropathic pain, fatigue, and autonomic dysfunction may appear after HPV vaccination.” Clinical Rheumatology 2015
https://www.ncbi.nlm.nih.gov/m/pubmed/26354426/


Human papillomavirus vaccines, complex regional pain syndrome, postural orthostatic tachycardia syndrome, and autonomic dysfunction – a review of the regulatory evidence from the European Medicines Agency.

“Recent concerns about a possible association between exposure of young women to human papillomavirus (HPV) vaccines and two “dysautonomic syndromes” (a collection of signs and symptoms thought to be caused by autoimmunity) – complex regional pain syndrome (CRPS) and postural orthostatic tachycardia syndrome (POTS) – led the European Medicines Agency (EMA) to review existing evidence.” Indian Journal of Medical Ethics 2017
https://www.ncbi.nlm.nih.gov/m/pubmed/27867145/


Hypothesis: Human papillomavirus vaccination syndrome–small fiber neuropathy and dysautonomia could be its underlying pathogenesis

“Clinicians should be aware of the possible association between HPV vaccination and the development of these difficult to diagnose painful dysautonomic syndromes.” Clinical Rheumatology 2015
https://www.ncbi.nlm.nih.gov/m/pubmed/25990003/


Neurologic Complications in HPV Vaccination

“The most common previous diagnosis in the patients was psychosomatic disease. Recently, delayed manifestation of cognitive dysfunction in the post-vaccinated girls has attracted attention. The symptoms include memory loss and difficulty in reading textbooks and/or calculation.” Brain and Nerve 2015
https://www.ncbi.nlm.nih.gov/m/pubmed/26160812/


Orthostatic intolerance and postural tachycardia syndrome as suspected adverse effects of vaccination against human papilloma virus.

“CONCLUSIONS: In a population referred for symptoms of orthostatic intolerance and other symptoms consistent with autonomic dysfunction that began in close temporal association with a quadrivalent HPV vaccination, we identified a 60% prevalence of POTS. Further work is urgently needed to elucidate the potential for a causal link between the vaccine and circulatory abnormalities and to establish targeted treatment options for the affected patients” Vaccine 2015
https://www.ncbi.nlm.nih.gov/m/pubmed/25882168/


Peripheral sympathetic nerve dysfunction in adolescent Japanese girls following immunization with the human papillomavirus vaccine.

“CONCLUSION: The symptoms observed in this study can be explained by abnormal peripheral sympathetic responses. The most common previous diagnosis in the studied girls was psychosomatic disease. The social problems of the study participants remained unresolved in that the severely disabled girls stopped going to school.” Internal Medicine Journal 2014
https://www.ncbi.nlm.nih.gov/m/pubmed/25274229/


Postural tachycardia syndrome following human papillomavirus vaccination

“CONCLUSION: Correct diagnosis of POTS and awareness that POTS may occur after vaccination in young women is essential for prompt and effective management of this condition.” European Journal of Neurology 2014
https://www.ncbi.nlm.nih.gov/m/pubmed/24102827/

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