Acute exacerbation of idiopathic pulmonary fibrosis after pandemic influenza A (H1N1) vaccination.

“We report a case of acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) after pandemic influenza (H1N1) vaccination.” International Medicine, 2010

Acute Lung Injury Accompanying Alveolar Hemorrhage Associated with Flu Vaccination in the Elderly.

“We herein describe a case of acute lung injury resulting from a pathologically confirmed alveolar hemorrhage, which may have been closely related to a preceding vaccination for pandemic influenza A of 2009/10. The present patient had been hospitalized with an acute lung injury after flu vaccination one year prior to the present hospitalization, however, he received another flu vaccination.” International Medicine, 2015

Adverse events following vaccination in premature infants.

“Vaccine-related cardiorespiratory events are relatively common in preterm babies. Problems were much more common if vaccine is administered at or before 70 d. These babies should therefore be monitored postvaccination.”

[Allergic alveolitis after influenza vaccination]

“We report a life-threatening complication in a female patient after influenza vaccination. The causative antigen was the influenza virus itself. Our Patient has suffered from exogen-allergic alveolitis for 12 years.” Pneumologie, 2009

Apnea after immunization of preterm infants.

“12 (12%) infants experienced a recurrence of apnea, and 11 (11%) had at least a 50% increase in the number of apneic and bradycardic episodes in the 72 hours after immunization.” Journal of Pediatrics, 1997

Beta-tryptase and quantitative mast-cell increase in a sudden infant death following hexavalent immunization.

“A fatal case of a 3-month-old female infant, who died within 24 h of vaccination with hexavalent vaccine is presented. Clinical data, post-mortem findings (acute pulmonary oedema, acute pulmonary emphysema), quali-quantitative data collected from immunohistochemical staining (degranulating mast cells) and laboratory analysis with a high level of beta-tryptase in serum, 43.3 microg/l, allows us to conclude that acute respiratory failure likely due to post hexavalent immunization-related shock was the cause of death.” Forensic Science International, 2008

[Cardiorespiratory events after first immunization in premature infants: a prospective cohort study].

“In this cohort of 41 premature infants whose mean gestational age was 30.8 weeks (SD: 1.9), 10 of these had a mild decrease in oxygen saturation or bradycardia; three developed a moderate cardiorespiratory event requiring tactile stimulation.” 2012

[Case Report; Influenza vaccination-associated acute lung injury: two cases report].

[Complications of pertussis immunization (author transl)].

“16 cases of neurological disease and/or death shortly after pertussis immunization are reported. Eight patients had convulsions, six with ensuing permanent defects. Severe polymyositis was observed in one case. Five infants died 12 h to 4 days after vaccination: two after acute encephalopathy and three in the form of a sudden unexpected death (SID). In two fatal cases the morphological changes in the brain corresponded to those of pertussis encephalopathy: neuronal degeneration in various parts of the cortex, especially in the region of the ammons horn, and in the cerebellum.”

Deaths Reported to the Vaccine Adverse Event Reporting System, United States, 1997-2013.

VAERS received 2149 death reports, most (n = 1469 [68.4%]) in children. Most common causes of death among 1244 child reports with available death certificates/autopsy reports included sudden infant death syndrome (n = 544 [44%]), asphyxia (n = 74 [6.0%]), septicemia (n = 61 [4.9%]), and pneumonia (n = 57 [4.6%]). Clinical Infectious Diseases, 2015.

Delayed life-threatening reaction to anthrax vaccine.

“We report a delayed and potentially serious life-threatening adverse reaction to anthrax vaccine. A previously healthy 34-year-old male was transported to the emergency department with dyspnea, diaphoresis, pallor, and urticarial wheals on his face, arms, and torso after the administration of the third dose of anthrax vaccine. Pharmaco-epidemiological data indicate that 30% of anthrax vaccine recipients experience mild local reactions. With large numbers of military personnel being vaccinated, emergency physicians may encounter more vaccine-related adverse reactions.” Journal of Clinical Toxicology, 2001

Fatal adult respiratory distress syndrome in a scalded child after immunization with attenuated virus (measles, mumps and rubella).

“A fatal adult respiratory distress syndrome (ARDS) occurred in a 15-month-old child who had suffered minor scalding during the febrile response to combined attenuated virus immunization (measles, mumps and rubella [MMR]). Despite vigorous efforts the child died 26 days after the accident. It is suggested that the scalding suppressed the normal immune response to the viremia and that the latter (i.e. most likely the measles viremia) caused the lung damage which, in turn, led to the ARDS.”

Imported Vaccine-Associated Paralytic Poliomyelitis — United States, 2005

“This report describes the first known occurrence of imported VAPP in an unvaccinated U.S. adult who traveled abroad, where she likely was exposed through contact with an infant recently vaccinated with OPV.”

“Upon admission to a hospital in Phoenix, the patient had bilateral areflexic lower extremity weakness and respiratory failure requiring intubation.”

Incidence of apnoea and bradycardia in preterm infants following triple antigen immunization.

“Ninety-seven preterm infants were immunized with diphtheria-tetanus-pertussis (DTP) prior to discharge from hospital. Nineteen (20%) infants developed apnoea or bradycardia within 24 h of immunization. The infants who developed apnoea and/or bradycardia had a younger gestational age at birth than those who did not (P = 0.03), were artificially ventilated for longer (P = 0.01) and were more likely to have a diagnosis of chronic lung disease (P = 0.006).”

Influenza vaccine-induced interstitial lung disease.

A 75-yr-old female was referred to our hospital (Komatsu Municipal Hospital, Komatsu, Japan) for evaluation of fever and chest radiograph abnormalities in November 2011. 2 weeks previously she had received the influenza vaccine. She had developed a fever 1 week before admission, and a chest radiograph revealed patchy airspace infiltrates in both lungs

Interstitial Pneumonia Associated with the Influenza Vaccine: A Report of Two Cases.

We encountered two cases of interstitial pneumonia that developed after vaccination during the 2014-2015 influenza season. [We found an increase in interstitial pneumonia incidence after 2009]. International Medicine, 2017

Lung pathology and immediate hypersensitivity in a mouse model after vaccination with pertussis vaccines and challenge with Bordetella pertussis.

Infection induced pathology; this induction was stronger after (especially WCV) vaccination. Vaccine, 2007

Mycobacterium bovis lymphadenitis complicating BCG immunization in an infant with symptomatic HIV-1 infection.

“A 3-month-old infant with HIV-1 infection who recently immigrated from Ethiopia developed regional lymphadenitis and systemic symptoms subsequent to BCG immunization. This case emphasizes the iatrogenic hazards of BCG immunization in HIV-1 infected infants. ”

Neonatal paralytic poliomyelitis. A case report.

“We report a child who became symptomatic with apnea at 18 days of age and who subsequently developed a permanent monoparesis. Serologic and cultural evidence indicated the virus as poliovirus vaccine type. Another infant who received live oral poliovirus vaccine was probably the source of the infecting virus.”

A Pneumonia Case Associated with Type 2 Polio Vaccine Strains.

This case investigation revealed that the patient received his first dose of tOPV on June 4 and the second dose on July 5, in accord with China’s immunization schedule. He was hospitalized in the Capital Institute of Pediatrics with pneumonia on June 31, which was 27 days after taking the first tOPV, and he had similar respiratory clinical symptoms within 35 days after his second dose of tOPV.;year=2017;volume=130;issue=1;spage=111;epage=112;aulast=Li

Possible predictors of cardiorespiratory events after immunization in preterm neonates.

“Immunization was performed on 31 very preterm infants, and was associated with an increased incidence (p < 0.01) of events lasting more than 10 s: bradycardia <80 bpm, desaturation and associated bradycardia-desaturation, with mild changes in HRV and no change in RRV.” “The increase in CR events after the first immunization in very preterm infants was associated with: (1) sympathetic predominance in heart rate control (high LF/HF ratio), (2) abnormal oversimplification of HRV (low entropy) and (3) persistent respiratory rhythm control immaturity (high IB+D before vaccine).

Potential risk of repeated nasal vaccination that induces allergic reaction with mucosal IgE and airway eosinophilic infiltration in cynomolgus macaques infected with H5N1 highly pathogenic avian influenza virus.

“On the other hand, eosinophil clusters were observed in the lungs of vaccinated macaques. Results suggest that we have to pay attention to potential allergic responses at repeated nasal vaccination, especially in people who have an airway allergy.”

Recurrence of cardiorespiratory events following repeat DTaP-based combined immunization in very low birth weight premature infants.

Thirty-three of the infants experienced a cardiorespiratory event after the first vaccination, and 6 of these 33 (18%) had a recurrence after the second vaccination, including 2 infants previously discharged to home. A cardiorespiratory event associated with the first vaccination was the sole risk factor for recurrence identified. Journal of Paediatrics, 2008

Vaccine-related adverse events in Cuban children, 1999-2008.

“The DTwP vaccine exhibited the highest rate of adverse events. Common minor events were: fever (17,538), reactions at injection site (4470) and systemic side effects (2422). Rare events (by WHO definition) reported were: persistent crying (2666), hypotonic-hyporesponsive episodes (3), encephalopathy (2) and febrile seizures (112). Severe events included: anaphylaxis (2), respiratory distress (1), multiple organ failure (1), sudden death (1), vaccine-associated paralytic poliomyelitis (2), toxic shock syndrome (3), and sepsis (1). The 10 deaths and 3 cases of disability were investigated by an expert commission, which concluded that 8 of the 13 severe events were vaccination-related.”

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